Midway by means of his vocation, Cees Dekker reinvented himself. Right after years of hardcore physics, he shifted his emphasis to ‘nanobiology’ at the switch of the millennium. A phrase he coined himself, to be a make a difference of actuality.
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‘It had been merely a matter of buying up a e book on cell biology and beginning to examine. I had originate from a earth of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Non-equilibrium folding of particular person DNA molecules recaptured nearly a thousand periods in a very stable point out nanopore
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and initially ever analyze on the dynamics DNA supercoils and the discovery of supercoil hopping
Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim in the pore is highlighted in red, in addition to a 3D rendering on the motion of your DNA rod is shown.
We use nanofabricated microfluidic buildings to sample spatial boundaries for micro organism and biomimetic vesicles with reconstituted protein networks and this assess the fundamental function of spatial confinement in the molecular and cellular amount. Our jobs involve the subsequent:
Finding out DNA loop extrusion by SMC proteins for chromosome architecture with one-molecule assays.
Knowing basic processes regulating the spatial and dynamic organisation in the DNA in Dwell cells.
But carbon nanotubes have remained a research subject matter of sizeable desire to quite a few. In fact, the outlook on employing carbon nanotubes to create functional gadgets, in locations like radio-frequency electronics, electronic electronics and versatile electronics, stays vibrant.
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
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Supercoiling-dependent DNA binding: quantitative modeling and purposes to bulk and solitary-molecule experiments